Full-size CIP/SIP Bioreactors 150L-300L-500L

SYSBIOTECH Pilot-scale Bioreactor is a reliable solution for working with cell culture-based process for scientific research and small biotech production facilities, as well as for scaling-up technology.

Standard «ready to use» solutions include all components needed for convenient operation with cell culture applications. After connecting the Bioreactor you can start using it right away without having to buy any accessories.

SYSBIOTECH Pilot-scale Bioreactors have fully aseptic design and can be validated easily. C-BIO2 control system, universal for any volume of Bioreactor greatly simplifies scale-up process and allows for easy transfer of cultivation data.

If needed, SYSBIOTECH Bioreactors can be upgraded to fulfill your specific application requirements.

For your convenience, all the necessary piping is installed on open stainless steel mobile frame. This helps to save space in your facility and simplifies access for maintenance of the Bioreactor.

All wetted surfaces are made of AISI 316L stainless steel with surface finish of 0.4 μm, to allow for effective CIP (cleaning-in-place).

Automated and user-configurable CIP and SIP (cleaning-in-place and sterilization-in-place) processing is standard included. A user-friendly program tool allows you to create your CIP and/or SIP sequence by defining its steps and set parameters. By combining sequences you can build a fully automated procedure for your entire application, maximizing day to day process consistency and ensuring best results.

Vessel (Height/Diameter: 1.5/1)

Total volume	150L/300L/500L
Working volume	105L/210L/350L
Materials	AISI 316L for wetted parts AISI 304L for non-wetted parts
Design pressure	3,0 kg/cm³ (vessel) 4,0 kg/cm³ (jacket)
Design temperature	143°С (vessel) 151°С (jacket)
Surface finish	Internal polishing Ra 0,4 μm (electropolished) External polishing Ra 1,2 μm

Components:

Top lid	Diaphragm Pressure Gauge
	Diaphragm Pressure Transmitter
	Rupture disk with outlet pipe
	Gases exhaust with condensor
	Inoculation
	Light glass
	Foam control with peristaltic pump
	CIP spray ball
Upper side walls	Air inlet
	Viewing glass
	Addition inlet
	Sparger (micro sparger)
Lower side walls	Temperature sensor PT100
	pH control with peristaltic pumps
	pO2 sensor
	Sterile sampling system
	Different sensors available on request: optical density, ORP, level, weight, conductivity, pCO2
Jacket	Steam inlet / Cooled water outlet
	Steam outlet / Cooled water supply (with safety valve and manometer)
Bottom	Sterializable bottom valve
Agitation unit	Mechanical or magnetic seal
	Manual/automatic speed control depending on the amount of dissolved oxygen.
	Speed range 20-200 RPM. Maximum speed calculated according application
	Different impeller types available on request
	3 welded baffles
Aeration unit	Automatic air O₂, CO₂supply
	5" absolute filter 0,2 μm and filter housing made from AISI 316L stainless steel
	Manual flow meter or automatic MFC (mass flow controller)
Piping	Material	Sanitary grade steel
	Piping construction	Air supply
		Plant steam supply
		Pure steam supply
		Cooling water supply
		Cooling water return
		Waste water drain
		Waste liquid drain
		Waste gas out
	Fittings	Diaphragm valve
		Angle seat valve
		Steam trap
		Diaphragm pressure gauge
		Ball valve and Pneumatic angle valve
		Check valve
		Safety valve
	Pipes welding	Orbital welding (product line)
		Manual welding (general line)

Main features:

Ready-to-work standard solutions with the ability to upgrade.
100% aseptic design, easy validation.
Different types of impellers: Rushton, marine-blade, pitched-blade right- and left-handed orientation with radial or axial flow.
Motor with single mechanical or magnetic seal guarantees 100% aseptic operation.
Mixing speed 30–600 rpm (standard option); up to 1,500 rpm upon request.
Standard sensors: temperature, pH, pO₂, and foam.
Sensors upon request: OD, ORP, level, weight, conductivity, pCO₂, gas analyzers.
5" absolute filters 0.2 μmto ensure purity of gas mixture inside the vessel.
Manual flow meter or automatic mass flow controller (MFC) to regulate supply of gas mixture.
Different sparger types including ring- or micro-spargers. Various specific designs are available upon request.
Two in-gold ports for housing any required electrodes.

C-BIO2^TMcontrol system features:

Universal control system for SYSBIOTECH’s bioreactors, independent of volume.
You can use either separate control system for each culture vessel, or one control system for several vessels (parallel experiments, individual vessel control).
The system is based on SCADA controller, constructed in conformance with industrial automation standards.
Simple and intuitive user interface provides quick access to all controllers and data.
Automation of the entire cultivation procedure using pre-programmed ‘sequences’ – for better control of your bioprocess.
The SCADA software ensures easy and reliable data management and control across all platforms.
Four level password control is included, to allow for administrator, manager, supervisor and user level authorization.

Full-size CIP/SIP Bioreactors 150L-300L-500L

RECOMMENDED PRODUCTS

TECHNOLOGICAL SCHEME

Full-size CIP/SIP Bioreactors 150L-300L-500L

RECOMMENDED PRODUCTS

TECHNOLOGICAL SCHEME

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