SYSBIOTECH industrial-scale bioreactors are a powerful tool for the process development and production. Our engineers work in close contact with you to meet all requirements for cell cultures cultivation. All our systems are custom-made in full accordance with your process demands and your business goals.
All wetted parts are made of 316L stainless steel with surface finish of Ra<0.8µm and Ra<0.4µm upon request. They have fully aseptic design and can be validated easily. Working volume ranges from 500 L to 150,000 L.
Advanced C-BIO2TM control system allows easy integration of upstream and downstream equipment in a unified production line: bioreactor, separation equipment, freeze-dryer and CIP-station.
All equipment can be monitored from one computer for comfortable process control. C-BIO2TM allows for easy transfer of cultivation data.
All equipment has SIP/CIP options and full cGMP and GAMP compliance. We provide all the associated documentation and conduct FAT and SAT.
If necessary, SYSBIOTECH bioreactors can be upgraded to fulfill your specific application requirements. You can install additional sensors or change impeller in your culture vessel.
For your convenience, all the necessary piping is installed on a single stainless steel frame. This simplifies access to the main technical units of the bioreactor.
|Vessel (Height : Diameter = 1.5:1 or 2:1):|
|Materials||AISI 316L for wetted parts|
|AISI 304 for non-wetted parts|
|Design pressure||3.0 kg/cm3 (vessel)|
|4.0 kg/cm3 (jacket)|
|Design temperature||143°С (vessel)|
|Surface finish||Internal polishing 0.4 μm (electropolished)|
|External polishing 1.2 μm|
|Valve EPDM / PTFE for diaphragm and FDA approved silicone for the gasket and O-rings|
20% of all product/WFI contact orbital welds are boroscope inspected and recorded
100% of manual welding are boroscope inspected and recorded
All welds are tagged
|Tagging||Stainless steel nameplate engraved with the tag or equipment number for each component.|
|Insulation||All tubing with temperature higher than 60°C (exclude the piping before steam trap) and lower than dew point have insulation protection shell|
|Top lid||Diaphragm Pressure Gauge|
|Diaphragm Pressure Transmitter|
|Gases exhaust with condensor|
|Agitation system (if upper agitation is chosen)|
|CIP Spray Ball|
|Upper side walls||Gases supply|
|Lower side walls||Temperature sensor|
|Sparger (ring or micro sparger)|
|Jacket||Temperature control system|
|Vessel insulation jacket|
|Closed loop temperature control system|
|Bottom||Common drain and biowaste drain via sterilizable bottom valve (self-drainable)|
|Agitation system (if bottom agitation is chosen)|
|Single/double mechanical or magnetic seal|
|Manual/automatic speed control depending on the amount of dissolved oxygen|
|Speed range 10–600 rpm. Up to 1,000 rpm available upon request|
|Marine, Rushton or pitched-blade impeller. Different impeller types available upon request.|
|3-4 welded or removable baffles|
|Automatic air supply up to 2 vvm|
|PTFE absolute filter 0.2 μm and filter housing made from AISI 316L stainless steel|
|Manual flow meter or automatic MFC|
|Material||Sanitary grade steel|
|Piping construction||Air supply|
|Plant steam supply|
|Pure steam supply|
|Cooling water supply|
|Cooling water return|
|Angle seat valve|
|Diaphragm pressure gauge|
|Pipes welding||Orbital welding (product line)|
|Manual welding (general line)|
C-BIO2TM control system features: